Single-cell RNA transcriptome revealed heterogeneity between primary and metastatic OS. (IMAGE)
Caption
(A) t-SNE visualization of major cell lineages. (B) The dot plots showing the average expression of 22 signature genes across the 10 cellular clusters. The dot sizes indicated the proportions of cells expressing the genes in each cluster and the color spectrum represented the mean expression levels of the signature genes. (C) Relative proportions of 10 clusters across primary and metastatic tissues as indicated. (D–F) t-SNE visualization of OB cell subsets (D), CB cell subsets (E), and OC cell subsets (F). (G–I) The dot plots showing the average expression of selected signature genes in OB cell subsets (G), CB cell subsets (H), and OC cell subsets (I). The dot sizes indicated the proportions of cells expressing the genes in each subset and the color spectrum represented the mean expression levels of the markers. (J, K) The dot plots showing the average expression of selected signature genes in myeloid cell subsets (J), and tumor-infiltrating lymphocyte subsets (K). (L, M) Dot plots showing average expression of selected signature genes in myeloid cell subsets (L), and tumor-infiltrating lymphocyte subsets (M). The dot sizes indicated the proportions of cells expressing the genes in each subset and the color spectrum represented the mean expression levels of the markers.
Credit
Linzhu Wang, Wenyue Li, Weihang Ji, Danyang Bing, Mingyue Liu, Kaidong Liu, Bo Chen, Zhangxiang Zhao, Yunyan Gu, Xuelian Li, Xiaoqiang E, Lei Yang
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