Dock8 mutants fragment and die. (VIDEO)

Institute of Science and Technology Austria

Caption

Dock8 mutants fragment and die. The video shows healthy (WT) and DOCK8 mutant dendritic cells (DOCK8-/-) migrating in collagen matrices, both in low and high magnification. While the WT cell moves in a typical ameboid fashion, the DOCK8 mutant forms very odd long protrusions, which result in fragmentation and eventually cell death. 

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© Nature Immunology/Reis-Rodrigues et al.

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