Increased miR-34a in the livers of patients with steatosis, MASH, and liver fibrosis. (IMAGE)
Caption
(A) Representative histological images of liver tissues from patients with steatosis, MASH, and liver fibrosis by hematoxylin-eosin or Masson's trichrome staining. The arrows mark the ballooned hepatocytes, and the circle mark the inflammatory monocyte infiltration. Scale bar, 25 μm. (B, C) Quantitative reverse transcription PCR analysis of mRNA expression of ApoB, ApoE, Ldlr, and miR-34a in the livers of controls and patients with steatosis, MASH, and liver fibrosis. Control, n = 3; steatosis, n = 7; MASH, n = 9; liver fibrosis, n = 9. Results represent mean ± standard deviation. The two-tailed student's t-test was used for statistical analyses of two-group comparisons. *P < 0.05, **P < 0.01, and ***P < 0.001 versus controls. ApoB, apolipoprotein B; ApoE, apolipoprotein E; MASH, metabolic dysfunction-associated steatohepatitis; Ldlr, low-density lipoprotein receptor.
Credit
Qihua Duan, Ruixiang Hu, Yan Chen, Henry Wade, Szczepan Kaluzny, Bingrui Zhang, Rongxue Wu, Guangnan Liu, Cunchuan Wang, Edward N. Harris, Qiaozhu Su
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