Anti-tumor effects of YK01 on U87-MG xenograft mouse models. (IMAGE)
Caption
(A) U87-MG xenograft mice were administered YK01 (12.5 mg/kg/d) and FX1 (25 mg/kg/d). (B) Tumor volumes (mm3) evaluated once every 2 days for a total of 22 days. (C) Tumors in each group. (D) Images of immunohistochemistry staining of Ki67. Scale bar = 50 μm. (E)Three tumor samples were selected from each of the four groups, and the expression of BCL6, PARP, c-MYC, and BCL2 were detected by western blotting. (F) Body weight changes of each group on day 21. (G) Hematoxylin-eosin staining of major organs of mice. Scale bars, 50 μm. (H) Liver function indexes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine (CR) were detected. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. "n.s." means no significance by log-rank (Mantel–Cox) test.
Credit
Min Wu, Lin Zhang, Weikai Guo, Shiyi Lv, Wangrui Jin, Shuangshuang Zhu, Huang Chen, Shuyi Jian, Layang Liu, Yajing Xing, Shihong Peng, Mingyao Liu, Yihua Chen, Zhengfang Yi
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