Distinct genomic profile analysis of CISD1 in various cancers. (IMAGE)
Caption
(A) Alteration frequency of CISD1 across various cancer types. The data were obtained from the cBio Cancer Genomics Portal (cBioPortal) database, showing the percentage of samples with mutations, structural variants, amplifications, and deep deletions in CISD1 across different cancer types. (B) Mutation frequency of CISD1 in different cancer types. The data from Tumor Immune Estimation Resource 2.0 (TIMER2.0) reveals the percentages of mutations of CISD1 in various cancers. (C) Mutation types and distribution in CISD1 across cancers. The data was analyzed using the SangerBox portal, showing the percentages of missense mutations, nonsense mutations, and splice sites across cancer types. (D) Protein domain analysis of CISD1 mutations. The mutation map generated from cBioPortal shows mutation types in the MitoNEET_N and zf-CDGSH domains. (E) mRNA expression analysis of CISD1 alterations in different cancer types. The results were obtained from SangerBox comparing neutral, gain, and loss alterations in various cancers. (F) The relationship between CISD1 expression and somatic mutations in BRCA (top) and LGG (bottom) cancers. The data from Comprehensive Analysis on Multi-Omics of Immunotherapy in Pan-cancer (CAMOIP) show the percentages of oncogene, tumor suppressor gene, and unknown gene types, and show the numbers of different mutation types such as splice site, missense, frameshift, inframe insertion/deletion, and nonsense mutations in the CISD1-high and CISD1-low groups.
Credit
Caiyue Li, Zhipin Liang, Gabrielle Vontz, Connor Kent, Wenbo Ma, Lei Liu, Riya Dahal, Jovanny Zabaleta, Guoshuai Cai, Jia Zhou, Huangen Ding, Qiang Shen
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