Representative immunohistopathology of the polyps. (IMAGE)
Caption
Polyp lesions with colibactin-producing E. coli (pks+, A–D) and without colibactin-producing E. coli (pks−, E–H) are shown. (A) Lymphocytes showing CD3-positive reaction infiltrating the mucosal lamina propria. (E) CD5-positive lymphocytes infiltrating the mucosal lamina propria. (B and F) γ-H2AX immunostaining. (I) The positive rate (%) of nuclei to the total number of adenoma cell nuclei is shown. (C and G) IL-6 immunostaining. (J) The immunoreactivity score (IRS) value was evaluated by IRS = (staining percentage score) × (staining intensity score) and shown. (D and H) IL-1ß immunostaining. (K) IRS values are shown. Bars, 50 µm. Figure permission is sought for the image.
Credit
By Hideki Ishikawa, Ryogo Aoki, Michihiro Mutoh, et al.
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC