Overexpression of Wnt target genes positively correlates with glioma grade and predicts worse patient survival. (IMAGE)
Caption
(A) The heatmap showing the differential expression of the Wnt proteins and the Wnt target genes between the GTEx cortex (n = 199) and TCGA-GBM (n = 173) datasets. (B) The spatial transcriptomic data showed the expression distribution of Wnt target genes in GBM tissues. The samples include GBM1 and GBM2 (UKF269_T and UKF334_T; Vidhya, 2022), and GBM3 (Patient 4; Yan, 2023). (C, D) The violin plot displaying the GSVA scores of Wnt target genes across RNA sequencing data from GTEx brain, TCGA_LGG, and TCGA-GBM datasets. ***P < 0.001. (E) Analyses of TCGA, CGGA, and Rembrandt datasets revealed that GSVA scores of Wnt target genes inversely correlated with glioma patient survival. The Wnt_target high- and low-expression groups were stratified based on the median GSVA score within each dataset.
Credit
Xiaowei Zhang, Zhongyong Wang, Taohui Ouyang, Brayden Wang, Richard I. Joh, Suyun Huang
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