Figure 2. Neuroprotective and tissue-restorative effects of KDS2010 (IMAGE)
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In the spinal cord injury animal model, administration of KDS2010 suppressed the injury-induced overexpression of MAOB in astrocytes and restored the expression of MAP2, a neuronal marker protein, thereby preserving neurons at the lesion site (a). Electron microscopy further revealed that demyelinated and disrupted axons were restored to near-normal myelinated structures (b–c). Quantitative g-ratio analysis confirmed that the abnormally thinned myelin was significantly thickened following treatment (d).
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