Administration of tirzepatide significantly attenuates hepatic lipid accumulation in MASLD mice. (IMAGE)
Caption
Effect of tirzepatide treatment on body weight (A) and liver weight (B) in mice with MASLD. Representative images of liver appearance (C), histological analysis via hematoxylin‒eosin (HE) staining (D), and lipid accumulation assessment via Oil Red O staining (E) are shown. (F) HepG2 cells were incubated with 0.2% BSA, 0.2 mM PA, or 0.2 mM PA supplemented with 5.6 nm or 42 nm tirzepatide for 24 h. Cellular lipid accumulation was visualized by Nile Red staining, and the average lipid content per cell was quantified using ImageJ software. n = 5 for A–E and n = 3 for F. Data are presented as mean ± SD. ns, not significant; Tir, tirzepatide.
Credit
Yun Li, Wencong Sun, Hong Liu, Xiong Z. Ruan
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