Novel way to ‘rev up’ brown fat burns calories, limits obesity in mice (IMAGE)
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A new study led by researchers at WashU Medicine reveals possible new avenues to exploit brown fat to treat metabolic diseases, such as obesity. Brown fat tissue from mice deficient in uncoupling protein 1 and fed a high-fat diet accumulates white fat droplets (left), a sign of impaired heat production. In brown fat from mice also deficient in uncoupling protein 1 but genetically engineered to have unusually high amounts of the protein ACOX2, white fat doesn’t build up on a high-fat diet (right) and heat production is better.
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Lodhi Lab
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