Simultaneous On and Off Gene Control with Gene Scissors​ (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

Simultaneous On and Off Gene Control with Gene Scissors​

Caption

< (A) A diagram of the violacein biosynthesis pathway, a functional biopigment produced from the starting material L-tryptophan through several enzymatic reactions. Violacein is a functional substance with broad applications in various industries and research fields, including medicine, healthcare, dyes, textiles, food and beverage, and cosmetics. (B) The results of a large-scale screening of gRNAs for gene activation and repression using the dual-mode CRISPR gene scissors system confirmed a 2.9-fold increase in violacein production (mg/L) upon rluC activation and a 3.0-fold increase upon ftsA repression compared to the control group. >

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KAIST

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