Wp1066 could reverse the tumor-promoting effect of NBL1 overexpression. (IMAGE)

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Wp1066 could reverse the tumor-promoting effect of NBL1 overexpression.

Caption

(A) The p-Stat3 and Stat3 protein expression with Wp1066 in ID8 NC and OE NBL1 cells by western blotting analysis. (B, C) Wound-healing assay showed the horizontal migration ability in ID8 NC and OE NBL1 cells with Wp1066. (D, E) CCK-8 assay showed the effect of Wp1066 on proliferation in ID8 NC and OE NBL1 cells. (F) Effects of Wp1066 on colony formation in ID8 NC and OE NBL1 cells. (G–I) Western blotting showed the effect of Wp1066 on EMT markers in ID8 NC and OE NBL1 cells. *P < 0.05, **P < 0.01, and ***P < 0.001. NBL1, neuroblastoma suppressor of tumorigenicity 1; EMT, epithelial to mesenchymal transition; Stat3, signal transducers and activators of transcription 3; p-Stat3, phosphorylated Stat3.

Credit

Yue Qi, Wenwen Zhang, Xinyu Li, Yi Shi, Pengpeng Qu

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