EUDAL Shields EGFR to Drive Drug Resistance in Oral Cancer (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

EUDAL Shields EGFR to Drive Drug Resistance in Oral Cancer

Caption

In normal conditions (left), EGFR is tagged by c-Cbl/Grb2 for breakdown inside lysosomes. In hypoxia (right), the RNA molecule EUDAL prevents this process, keeping EGFR permanently active. This activates the STAT3/BNIP3 pathway, triggering autophagy and allowing oral cancer cells to resist chemotherapy.

Credit

Prof. Zhiyuan Zhang and Dr. Qin Xu from Shanghai Jiao Tong University, School of Medicine, Shanghai, China Image source link: https://doi.org/10.1038/s41368-025-00396-2

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.