Retrograde trafficking pathways from the plant vacuole and endosomes. (IMAGE)
Caption
This study revealed two independent retrograde pathways: a sorting nexin–mediated pathway (orange) and a core retromer–mediated pathway (blue). In yeast, sorting nexins and the core retromer form a single complex that functions in endosome-to-Golgi retrograde transport. In contrast, our findings demonstrate that in plants, SNX and the core retromer operate independently, mediating distinct retrograde routes with different cargo proteins. Together, these pathways establish and maintain the unique membrane protein compositions of vacuoles and endosomes.
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Ueda Lab, NIBB
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