Diseases associated with cholesterol metabolism. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Diseases associated with cholesterol metabolism.

Caption

This figure summarizes major diseases caused by cholesterol metabolism disorders, including familial hypercholesterolemia from LDLR mutations, atherosclerosis due to oxidized LDL deposition, gallstone formation from bile supersaturation, NAFLD from hepatic lipid accumulation, Alzheimer’s disease linked to excess cholesterol and Aβ buildup, and cancer driven by cholesterol synthesis and signaling dysregulation.

Credit

Zhiguang Su

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