Figure 4. Challenges and future directions in the field of druggable target screening. (IMAGE)
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Figure 4. This figure outlines the current challenges encountered in the research field of druggable target screening methods and four key future directions. It emphasizes model ensembles and algorithmic improvements, the simulation of protein dynamic conformations and mining of cryptic sites, multisource information integration and high-throughput screening, and the construction of efficient computational-experimental validation pipelines and standardized evaluation systems.
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Anqi Lin, Zhirou Zhang, Aimin Jiang, Kexin Li, Ying Shi, Hong Yang, Jian Zhang, Rongrong Liu, Yaxuan Wang, Antonino Glaviano, Quan Cheng, Bufu Tang, Zhengang Qiu, Peng Luo
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