Image 4 (IMAGE)

National University of Singapore, Yong Loo Lin School of Medicine

Image 4

Caption

More immune cells migrated into the lung tumours after a laboratory model was treated with combined KRAS inhibition and RIG-I activation

1st column: H&E staining showing more tumours (dense clusters of cells with large, dark nuclei) in the lung tissue of untreated model.

2nd column: Analysis of H&E images using QuPath software shows fewer tumours and more immune cells (which help fight cancer) in the lungs of treated models compared to control group.

3rd and 4th columns: Treated models show more infiltration of two main cancer-fighting cells in the lungs: natural killer (NK) cells (brown, 3rd column) and cytotoxic T cells (brown, 4th column) compared to control group. Blue colour indicates nuclei stained by Haematoxylin, allowing visualisation of all cells.

(Credit: Dai Phung and Trinh Tran, Department of Pharmacology, NUS Medicine).

Credit

Dai Phung and Trinh Tran, Department of Pharmacology, NUS Medicine

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