Lateral inhibition restrains microglial proliferation and migration, and microglia replacement can be achieved using donor cells from different sources. (IMAGE)
Caption
In the microglia fully tiled brain, the proliferation and migration of microglia are inhibited by their neighboring cells. When the neighboring microglia are removed, the lateral inhibition is released, enabling microglial proliferation and migration towards the microglia-free region. The source of donor cell for microglia replacement includes bone marrow cells, peripheral blood cells, primary microglia, and ESC or iPSC-derived microglia.
Credit
Bo Peng et al.
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