ASO-A (IMAGE)

Cold Spring Harbor Laboratory

ASO-A

Caption

The Krainer lab developed 12 initial ASO drug candidates. The best performing ASO—ASO-A—completely broke the SRSF1-AURKA-MYC circuit, leading to slower tumor growth and cell death. Left: Untreated PDAC tumor organoid. Right: PDAC tumor organoid after treatment with ASO-A.

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Krainer lab/CSHL

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