Figure 2 (IMAGE)
Caption
Schema of three EML4-ALK variants observed by HS-AFM.
All three variants demonstrated dynamic, reversible transitions between monomeric, dimeric, and trimeric states. We identified a previously uncharacterized TFG subdomain within the EML4 that may be causally linked to the diverse patterns of oligomerization observed for the ALK domains. Conversely, ALK inhibitors such as alectinib compacted the EML4 and suppressed EML4-ALK oligomerization, providing a molecular basis for its activity.
Credit
Figure created by the authors based on data from Xujun Han et al. (2026).
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