Figure: Sex Differences in Motor Unit Firing Behavior in Parkinson's Disease: Neural Pathways, HD-sEMG Decomposition, and Distinct Gender-Specific Physiological Markers. (IMAGE)

Kanazawa University

Figure: Sex Differences in Motor Unit Firing Behavior in Parkinson's Disease: Neural Pathways, HD-sEMG Decomposition, and Distinct Gender-Specific Physiological Markers.

Caption

This study utilized high-density surface electromyography and motor unit decomposition to investigate sex differences in motor unit firing behavior in patients with Parkinson’s disease. Females exhibited greater asymmetry in firing properties between more- and less-affected sides, including lower estimates of persistent inward currents (ΔF), higher discharge rates, and increased interspike interval variability. In contrast, males demonstrated more symmetrical and stable motoneuron activity.

Credit

©Adapted from Yuichi Nishikawa et al., European Journal of Neuroscience, 2025, licensed under CC BY 4.0.

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CC BY

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