Hi-C analysis and schematic of genome organisation (IMAGE)

Medical Research Council (MRC) Laboratory of Medical Sciences

Hi-C analysis and schematic of genome organisation

Caption

A) A Hi-C contact heatmap showing how often DNA regions touch in 3D space in a mouse somatic cell (normal body cell) and a germ cell (a cell which will become sperm or an egg), where the diagonal line shows nearby regions interacting and larger squares or dots highlight folded domains and long-range loops in chromosome organisation. B) A schematic of the genome architecture shows how chromosomes become more separated in distance inside the nucleus. Centromeres are constricted regions of chromosomes; distal telomeres are protective DNA sequences at the end of chromosomes and H3K9me3 pericentromeric heterochromatin is tightly packed DNA near centromeres (Huang et al., 2026).

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Tien-Chi Huang, MRC Laboratory of Medical Sciences

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