Pyroptosis occurs primarily in hepatocytes and inflammasomes are formed predominantly in macrophages in the liver of Atg14 HepKO mice. (IMAGE)

First Hospital of Jilin University

Pyroptosis occurs primarily in hepatocytes and inflammasomes are formed predominantly in macrophages in the liver of Atg14 HepKO mice.

Caption

(A–F) IF analysis of GSDMD, GSDME and NLRP3 in hepatocytes and macrophages in the liver of WT and Atg14 HepKO mice fed a Western diet for 4 weeks (n=5). Data were represented by mean±SE. ***p<0.001 for WT versus HepKO. ALB, albumin; ATG14, autophagy related 14; DAPI, 4′,6-diamidino-2-phenylindole; GSDMD, gasdermin D; GSDME, gasdermin E; HepKO, hepatocyte-specific knockout; IF, immunofluorescence; NLRP3, NLR family pyrin domain containing 3; WT, wildtype.

Credit

By Barry Stein, Jun Wan, Xiaocheng Charlie Dong, et al.

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CC BY-NC

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