Fig. 2 (IMAGE)

The University of Osaka

Fig. 2

Caption

Binding kinetics of KCNQ2/3 to ankG depend on channel functionality. KCNQ2/3 with normal functionality binds more stably to ankG. This promotes exocytic insertion of KCNQ2/3 at the AIS surface while suppressing its endocytic internalization. In contrast, reduced KCNQ2/3 functionality impairs its binding to ankG, leading to decreased insertion and enhanced internalization at the AIS surface.

Credit

Daisuke Yoshioka et al., 2026, Coupling of Functionality to Trafficking of KCNQ2/3 Potassium Channels at the Axon Initial Segment, Proceedings of the National Academy of Sciences

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