SELEX technology to generate NfL-specific DNA aptamers for easy Alzheimer's detection (IMAGE)

Tokyo University of Science

SELEX technology to generate NfL-specific DNA aptamers for easy Alzheimer's detection

Caption

Researchers used a seven-round SELEX process to generate DNA aptamers that specifically recognize NfL, a key blood-based biomarker for Alzheimer's disease. Two lead aptamers, MN711 and MN734, emerged with binding affinity comparable to commercial anti-NfL antibodies.

Credit

Dr. Kaori Tsukakoshi from Tokyo University of Science, Japan, and Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology, Japan Image source link: https://www.sciencedirect.com/science/article/pii/S0006291X25018674

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