Spatial mapping reveals the complex cellular landscape of prostate tumours. (IMAGE)
Caption
These images represent the cellular “atlas” detailed in the study. Using advanced spatial transcriptomics, researchers mapped the exact physical locations of different cell types and structures within various prostate tissue samples.
This level of detailed mapping allows researchers to see how different cells – from the glandular lining to the structural tissue and nerves – are physically organised and interact within the early stages of cancer development.
Note: The specific colours used vary between individual patient samples to provide the best visual contrast for each distinct tissue region (such as benign tissue, Gleason Grade 3, and Gleason Grade 4 cancer).
Labels indicate:
- Epi Benign = Benign epithelium (healthy glandular lining cells)
- GG3 = Gleason Grade 3 (early-stage cancerous cells)
- GG4 = Gleason Grade 4 (more advanced cancerous cells)
- GG4 cribriform = Gleason Grade 4 cribriform (a specific, more aggressive structural pattern of advanced cancer cells)
- Stroma prostatic = Structural connective tissue within the prostate
- Stroma extraprostatic = Structural tissue outside the prostate
- Vessel = Blood vessels
- Adipose = Fat tissue
- Excluded = Areas outside the tissue or empty spaces/lumens
Credit
Garvan Institute
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License
CC BY-NC-SA