Construction of the CIN score. (IMAGE)
Caption
(A, B) Thirty-two genes were selected for multivariate COX regression analysis via the LASSO algorithm. (C) The expression of 13 genes in the two CIN score groups was visualized by a heatmap. (D) Forest plot of multivariate Cox results for 13 genes in the CIN score. (E) CIN score distribution is sorted from lowest to highest (upper). Survival status for each BC patient is categorized by CIN score (lower). (F) Sankey diagram correlating clusters, CIN score, and BC survival status. (G) The Kaplan–Meier curve comparing overall survival (OS) between low- and high-CIN score groups. (H) ROC curves depicting predictive performance of CIN score for 1, 3, and 5-year OS. (I–N) The comparisons of common clinicopathological factors: age (I), T stage (J), N stage (K), pathological stage (L), HER2 status (M), and PAM50 subtype (N) between the two groups.
Credit
Huiling Wang, Huijuan Dai, Yaohui Wang, Qiong Wu, Mingxi Zhu, Wenjin Yin, Jinsong Lu
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CC BY-NC-ND