PANDORA-seq unveils sncRNA alteration signatures in AZS and TZS compared with NZS (IMAGE)

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PANDORA-seq unveils sncRNA alteration signatures in AZS and TZS compared with NZS

Caption

(A) The uniform manifold approximation and projection (UMAP) plot visualizing the distribution of human sperm total sncRNAs among healthy controls (NZS, n = 9), AZS samples (n = 9), and TZS samples (n = 7). (B) Dynamic landscapes and length distributions of miRNAs, tsRNAs, and rsRNAs detected. Zoomed panels of miRNA and tsRNA are shown on the plot for clearer visualization. (C) The radar plot showing the expression proportions (normalized by NZS samples) of each tsRNA subcategory in AZS and TZS samples. (D) The heatmap showing Spearman correlation coefficients between tsRNA subcategory abundances. (E) The bar charts showing the expression proportions of six nucleus-encoded rsRNAs and two mitochondria-encoded rsRNAs among NZS, AZS, and TZS. (F) The heatmap showing Spearman correlation coefficients between the rsRNA origin abundances. (G) The heatmap showing expression profile changes in miRNAs based on a log2-transformed scale among NZS, AZS, and TZS. (H) The heatmap showing Spearman correlation coefficients between the top 20 miRNA family abundances.

Credit

Ruofan Huang, Yiting Yang, Wenlin Jiang, Zheng Cao, Junchao Shi, Xiao-Ou Zhang, Yunfang Zhang

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