Elevated B7x mRNA expression correlates with poor prognosis in advanced or metastatic muscle-invasive bladder cancer (MIBC) patients (IMAGE)
Caption
(A) Kaplan–Meier survival analysis of MIBC patients from the TCGA-BLCA dataset, stratified by B7x mRNA expression; B7xhigh (n = 101 patients, 1st quartile) and B7xlow (n = 102 patients, 4th quartile). Log-rank test was used. (B) The heatmap illustrating demographic and clinical characteristics of the patients in (A), divided by B7x expression levels. Chi-squared or Fisher’s exact test was applied. ∗ indicates P-value statistical significance. (C) The violin plots comparing insertion-deletion and single-nucleotide variant mutations between high and low B7x expression groups. Each dot represents an individual patient. The Mann–Whitney U test was used; P values are indicated. (D) The heatmap illustrating mutation process cluster, APOBEC mutation load, and neoantigen load of the patients in (A), categorized by B7x expression levels. Chi-squared test was used.
Credit
Marc C. Pulanco, Xiang Yu Zheng, Alexander Sankin, Deyou Zheng, Xingxing Zang
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