Two human embryos, showing the effect of NANOG gene (IMAGE)
Caption
In the normal embryo (left): magenta cells will become the placenta, yellow cells will become the yolk sac, and cyan cells will become the epiblast, which later forms the body.
In the embryo where genome editing was used to block NANOG (right): no cyan cells were seen - the epiblast could not develop. Loss of NANOG did not significantly affect the development of cells that would become the yolk sac or placenta, the tissues that support the developing embryo.
Credit
Loke Centre for Trophoblast Research, University of Cambridge.
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