KAIST Uncovers the “Hidden Key” to Immunotherapy for Intractable Brain Tumors (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

KAIST Uncovers the “Hidden Key” to Immunotherapy for Intractable Brain Tumors

Caption

Figure 2. Anti-CTLA-4–induced B-cell immune responses in tumor-draining lymph nodes and antitumor immune responses within brain tumors in mouse glioma models

(A) Comparison of survival and brain tumor burden between wild-type and B-cell-deficient mice following anti-CTLA-4 treatment
(B) Analysis of changes in B cells, germinal center B cells, and T follicular helper cells in tumor-draining lymph nodes following anti-CTLA-4 treatment
(C) Analysis of immunoglobulin G (IgG) distribution in brain tumor tissue and of IgG-bound glioma cells following anti-CTLA-4 treatment
(D) Establishment of an mCherry-EGFP dual-reporter glioma model and analysis of tumor cell phagocytosis by intratumoral phagocytes following anti-CTLA-4 treatment

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KAIST

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