IRP1-ARID3A-CYGB axis plays an important role in PCa. (IMAGE)
Caption
(A–C) IRP1, ARID3A, and CYGB expression levels were detected by immunohistochemistry in PCa tissue microarrays. (D) High expression of IRP1 is associated with poor prognosis of PCa patients. (E) High expression of ARID3A is associated with poor prognosis of PCa patients. (F) Low expression of CYGB is associated with poor prognosis of PCa patients. (G) Correlation analysis of ARID3A and IRP1. (H) Correlation analysis of CYGB and IRP1. (I) Correlation analysis of CYGB and ARID3A. (J) Transcriptional inhibition of CYGB by IRP1/ARID3A leads to PCa cells resistant to ferroptosis and chemotherapy. PCa, pancreatic cancer.
Credit
Zeru Li, Cheng Qin, Bangbo Zhao, Tianyu Li, Yutong Zhao, Lirui Huang, Haoyu Shi, Yiping Xie, Yutong Yan, Xiangyu Zhang, Weibin Wang
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