ADAR1 is aberrantly overexpressed in liver cancer tissues and associated with poor prognosis (IMAGE)
Caption
A–C) Analysis of ADAR1 expression abundance across human cell lineages by single-cell RNA sequencing. (A) Cell lineage markers. (B) Expression pattern of ADAR1 across distinct cell populations. (C) Median expression levels of ADAR1 in different cell clusters. (D) Analysis of the GEPIA database demonstrating relative ADAR1 levels in hepatocellular carcinoma (HCC) tumor tissues (red box, n = 369) versus normal tissues (gray box, n = 160). (E) ADAR1 protein expression levels in paired clinical HCC tumor tissues (T) and adjacent non-tumor tissues (N) (n = 8). This experiment was performed with at least three biologically independent replicates (n ≥ 3). (F) Representative immunohistochemical staining images from the HPA database. Scale bar: 100 μm. (G) Overall survival analysis of HCC patients stratified by ADAR1 expression levels in the GEPIA database.
Credit
Jing Liu, Yongle Zhao, Xue Gong, Lin Yuan, Shengyong Yang, Wenwen Jian, Han Yan, Honglin Chen, Zhicheng Yang, Yiheng Sun, Tianle Gu, He Lu, Hongyun Zhao, Zeng Tu
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