How targeted mRNA-LNPs can generate CAR-T cells inside the body (IMAGE)

Science China Press

How targeted mRNA-LNPs can generate CAR-T cells inside the body

Caption

A targeted LNP carries CAR-encoding mRNA to a T cell. After cellular uptake and endosomal release, the mRNA is translated in the cytoplasm and CAR protein is displayed on the cell surface, creating a transient CAR-T cell that can recognize and kill target cells.

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