Vitamin A Metabolite Preserves T Cells’ Function as KAIST Points to a New Strategy for Treating Intractable Brain Tumors (IMAGE)
Caption
Figure 2. ATRA's Effect on Preserving CD8⁺ T-Cell Function and Its Combined Effect with Anti-PD-1 Therapy, Confirmed in Mouse Glioma Models
(A) Oral ATRA administration improved survival and tumor suppression in glioma-bearing mice. (B) In mice given oral ATRA, tumor-infiltrating CD8⁺ T-cell numbers increased, exhaustion markers improved, and cytotoxic capacity was enhanced. (C) In a model of post-surgical recurrent brain tumors, combining oral ATRA with anti-PD-1 therapy improved treatment outcomes.
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KAIST
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