Overview of 3D in vitro models for studying TME interactions (IMAGE)

International Society for Health Data Science

Overview of 3D in vitro models for studying TME interactions

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 (A) Modeling tumor-stroma interactions of the TME in organoid cocultures. (B) Modeling tumor-immune interactions in organoid cocultures for evaluating immunotherapeutic drugs. (C) Modeling vascularized organoids and perfusion using microfluidic devices or 3D bioprinting. (D) Modeling interactions of multiple cell types within coculture systems. (E) Phenotypic analysis of organoid coculture models includes organoid growth evaluation, histological assessment, multiomics profiling, and gene editing for mechanistic studies as well as spatial transcriptomics, multiplexed immunofluorescence/proteomics, and AI-driven high-content 3D imaging. 3D, three-dimensional; AI, artificial intelligence; ICIs, immune checkpoint inhibitors; MHC, major histocompatibility complex; TIME, tumor immune microenvironment; and TME, tumor microenvironment.

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Dong Chen, Zhuo Yang

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