Major zygotic gene activation and embryonic development through temporary nuclear softening (IMAGE)
Caption
Researchers found that during the two-cell stage of the mouse embryo, the nuclear envelope becomes soft and plastic. Lamin B1 is one of the proteins that give structure to the nuclear envelope. At the two-cell stage, Lamin B1 is cleared from the nuclear envelope by the protein LC3, causing the nucleus to soften. This softening is vital for major zygotic gene activation and subsequent development of the embryo.
Credit
Kyushu University/Kei Miyamoto, National Institute of Genetics/Yuta Shimamoto
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