肠道微生物代谢物 UDP-GlcNAc 劫持宿主"糖开关"（O-GlcNAc 糖基化修饰）助推乳腺癌进展与化疗耐药 (IMAGE)

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肠道微生物代谢物 UDP-GlcNAc 劫持宿主"糖开关"（O-GlcNAc 糖基化修饰）助推乳腺癌进展与化疗耐药

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肠道内的乳酸瘤胃球菌合成 UDP-GlcNAc 并进入血液循环，激活宿主酶 OGT。OGT 介导的糖基化修饰稳定转录因子 NFIB，后者上调 OGT 与原癌基因 KIT 的表达，形成正反馈环路，驱动乳腺癌增殖、侵袭、迁移及紫杉醇耐药。抑制 OGT 可阻断该促癌轴。

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