IRF2 Deficiency (IMAGE) Tokyo Medical and Dental University Caption A. Flow cytometric analysis revealed that the number of ISCs was reduced in Irf2-/- mice compared with control mice. Lgr5-GFP: reporter fluorescence of ISCs. B. Sections of the jejunum from control (left) and Irf2-/- (right) mice, 6 days after the induction of epithelial injury by 5-fluorouracil administration, were stained with Ki67. The number of Ki67-stained regenerated crypts were substantially reduced in Irf2-/- mice compared with control mice. Credit Department of Biodefense Research,TMDU Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.