Figure 1. An IRF2 deficiency reduces intestinal stem cells (ISCs) and attenuates crypt regeneration after injury. (IMAGE)

Tokyo Medical and Dental University

Figure 1. An IRF2 deficiency reduces intestinal stem cells (ISCs) and attenuates crypt regeneration after injury.

Caption

A. Flow cytometric analysis revealed that the number of ISCs was reduced in Irf2-/- mice compared with control mice. Lgr5-GFP: reporter fluorescence of ISCs. B. Sections of the jejunum from control (left) and Irf2-/- (right) mice, 6 days after the induction of epithelial injury by 5-fluorouracil administration, were stained with Ki67. The number of Ki67-stained regenerated crypts were substantially reduced in Irf2-/- mice compared with control mice.

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Department of Biodefense Research,TMDU

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