The Function of NOTCH is Crucial for Valve Development (IMAGE)

Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

The Function of NOTCH is Crucial for Valve Development

Caption

The function of NOTCH is crucial for valve development. (A) NOTCH action occurs in 2 phases, early (E9.5-10.5) and late (E14.5-birth), which involve the activation of the receptor by distinct ligands. E9.5, E10.5, etc. indicate the day of embryonic development in the mouse. (B) Early valve development via the process of epithelial to mesenchymal transition (EMT), giving rise to the primitive valves at E9.5 (E22 in humans). (C) From E11.5 (E33 in humans), NOTCH negatively regulates the proliferation of valve tissue; inactivation of this pathway triggers an overproliferation of valve tissue and eventually the formation of a bicuspid aortic valve (BAV). (D) Normal aortic valve at E15.5 (E55 in humans); arrowheads mark the 3 valve leaflets. (E) Bicuspid aortic valve in a NOTCH mutant; as a result of overproliferation and fusion, only 2 valves are present (arrowheads).

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