The Deformability of the Cell Nuclei Is a Limiting Factor for Cell Invasion (VIDEO)
Caption
This is a time-lapse microscopy movie of human breast cancer cells migrating into channels of different widths (20um, 10um and 5um). The far left panel show scells moving easily into channels that are 20um wide. The central panel shows that cells take longer to migrate into the smaller 10um size channels. The far right panel shows cells are unable to migrate into 5um wide panels and protrude their cytoplasm into the channel, but the nuclei remain outside the channel. This indicates that the size and deformability of the cell nuclei acts as a limiting factor for cells to squeeze into small spaces.
Credit
Jayo et al.
Usage Restrictions
Credit Required.
License
Licensed content