Fibroblast Cells Use Fascin to Move Their Nuclei (VIDEO)
Caption
This is a fluorescent time-lapse movie of the actin cytoskeleton in fibroblast cells. Cells in the right panel are expressing the actin-binding protein fascin, cells in the left panel have been depleted of fascin using shRNA. Movies show that cells that express fascin use the actin cytoskeleton to move their nuclei backwards during migration to allow the cells to move forward, and that this does not occur when fascin is removed from cells. This shows that fascin is important in controlling the movement of the cell nucleus and this contributes to the ability of cells to migrate.
Credit
Jayo et al.
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