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Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

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The figure represents the association of the respiratory complexes I, III and IV associated to form the N-respirasome super complex. The presence or absence of the SCAF1 protein determines the efficiency in the use of the energy source (food) to convert it into productive work by keeping complexes III and IV physically connected within the N-respirasome. SCAF1 would work like the gears of a motorcycle allowing efficient regulation of performance.

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CNIC

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