In Mice, Targeting Inflammation Linked to Parkinson's Disease Reduces Brain Cell Death (2 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

In Mice, Targeting Inflammation Linked to Parkinson's Disease Reduces Brain Cell Death (2 of 3)

Caption

Disease-causing Lewy-body like aggregates (red) adjacent to dopamine producing neurons (green). Inhibiting inflammasomes with MCC950 reduced these protein aggregates and prevented the loss of dopamine neurons. This material relates to a paper that appeared in the Oct. 31, 2018, issue of Science Translational Medicine, published by AAAS. The paper, by R. Gordon at University of Queensland in St. Lucia, QLD, Australia; and colleagues was titled, "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice."

Credit

Dr. Richard Gordon and Trent Woodruff

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