Cancer Gene Drives Vascular Disorder (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Cancer Gene Drives Vascular Disorder (2 of 2)

Caption

<i>PIK3CA</i> mutations impair blood vessel formation in mouse embryos (upper panels). Here, the mutations improved after treatment with a PI3K&alpha; inhibitor (lower panels). This material relates to a paper that appeared in the 30 March 2016, issue of <i>Science Translational Medicine</i>, published by AAAS. The paper, by P. Castel at Memorial Sloan Kettering Cancer Center in New York, NY, and colleagues was titled, "Somatic <i>PIK3CA</i> mutations as a driver of sporadic venous malformations."

Credit

P. Castel <i>et al., Science Translational Medicine</i> (2016)

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