(VIDEO)
Caption
The video is created by time-lapse imaging during myogenic differentiation of gene-corrected dystrophic muscle stem cells (satellite cells). Each muscle stem cell is marked by expression of a red fluorescent protein after expansion in culture and gene-correction. Gene-corrected dystrophic muscle stem cell fuse to each other and form DYSTROPHIN-expressing multinucleated myotubes in culture. This material relates to a paper that appeared in the Jan. 1, 2016 issue of Science, published by AAAS. The paper, by M. Tabebordbar at Harvard University in Cambridge, MA, and colleagues was titled, "In vivo gene editing in dystrophic mouse muscle and muscle stem cells."
Credit
Mohammadsharif Tabebordbar
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