Anti-Sema4D antibody induces metastasis (IMAGE)

IDIBELL-Bellvitge Biomedical Research Institute

Anti-Sema4D antibody induces metastasis

Caption

Due to the treatment with the antibody against Semaphorin 4D (anti-Sema4D), changes occur in the tumor vasculature as well as a decrease in tumor volume. However, this decrease is accompanied by an increase in tumor invasion and metastasis. This effect is a consequence of the activation of intratumoral macrophages (TAMs), which in response to anti-Sema4D increase the secretion of SDF1 protein, associated with greater malignancy of the tumor

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Iratxe Zuazo

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