Anti-Sema4D antibody induces metastasis (IMAGE) IDIBELL-Bellvitge Biomedical Research Institute Caption Due to the treatment with the antibody against Semaphorin 4D (anti-Sema4D), changes occur in the tumor vasculature as well as a decrease in tumor volume. However, this decrease is accompanied by an increase in tumor invasion and metastasis. This effect is a consequence of the activation of intratumoral macrophages (TAMs), which in response to anti-Sema4D increase the secretion of SDF1 protein, associated with greater malignancy of the tumor Credit Iratxe Zuazo Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.