Enzyme Controls Food Intake and Drives Obesity (IMAGE)

American Association for the Advancement of Science (AAAS)

Enzyme Controls Food Intake and Drives Obesity

Caption

Littermates (siblings) were injected with either a control virus (right) or a virus that knocked out O-GlcNAcTransferase (OGT) (left) in a subpopulation of cells in the hypothalamus in the brain (&alpha;CaMKII-positive paraventricular neurons). OGT knock out made the mouse eat twice as much as its sibling. This photo was taken about five weeks after virus injection. This material relates to a paper that appeared in the March 18, 2016, issue of <i>Science</i>, published by AAAS. The paper, by O. Lagerl&ouml;f at Johns Hopkins University School of Medicine in Baltimore, Md., and colleagues was titled, "The nutrient sensor OGT in PVN neurons regulates feeding."

Credit

Olof Lagerlof

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