Zika Virus Replication Factories (IMAGE)

Cell Press

Zika Virus Replication Factories

Caption

This visual abstract depicts the findings of Cortese et al., who show that Zika virus infection in both human hepatoma and neuronal progenitor cells induces drastic structural modification of the cellular architecture. Microtubules and intermediate filaments surround the viral replication factory composed of vesicles corresponding to ER membrane invagination toward the ER lumen. Importantly, alteration of microtubule flexibility impairs Zika replication.

Credit

Cortese et al./<i>Cell Reports 2017</i>

Usage Restrictions

Credit Required.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.